PRODUCT STRENGTH (CONCENTRATION)
SARM WS 23 N-2,3-trimethyl-2-isopropylbutamide 100mg/ml
WHAT ARE THE KEY BENEFITS?
- Food Approved
- Promotes fullness and hardness
- Clinical evidence of activity
- Long acting
(w)S-23 is suitable for use by both males and females.
WHAT IS IT?
WS-23 is a TRPM8 agonist.
In fact, it is one of the most potent TRPM8 agonists, three times more potent than the ligand - menthol, withactivity extending over several hours.
TRPM8 (Transient Receptor Potential cation Channel Member 8) is an androgen receptor involved in thedetection and measurement of cold temperatures.
It is related to cell proliferation, cell growth and anabolic activity.
TRPM8 also regulates energy metabolism and controls the clock gene and clock controlled genes in brown adipose tissue. This is achievedthrough upregulation of REV-ERBα/β genes.
The recently prohibited substances - SR9009 and SR9011, were observed to affect circadian expression of several core clock genes in thehypothalamus of mice. These genes were responsible for regulating circadian rhythms, such as sleep patterns, and various other functionsand activities which rely on the internal body clock.
Dose-dependent suppression of the REV-ERB target plasminogen activator inhibitor 1 gene was observed in the liver in response to treatmentof mice with various doses over 6 days. Observations obtained when mice were kept under light:dark (12 h:12 h) conditions or completedarkness indicated that the effect of light on the circadian oscillator had a significant effect on the drug action.Moreover, circadian genes associated with adipose tissue storage were found to be suppressed during treatment with the compounds.
Modulation of REV-ERB, CLOCK and CLOCK-like gene expression is further evidenced by menthol’s modulation of the sleep/waking cyclesof various species with genes conserved in humans.
It is reasonable to assume that the higher affinity for the TRPM8 and longer half-life in regard to metabolism, SR900Prime confers evengreater activity and comparable efficacy with SR9011.
ADMINISTRATION OF PRODUCT
Recommended dosage is 1ml (one full dropper) daily with food, administered in the morning, and mixed into 250ml juice, protein shake, orpre-workout.
- For leanness: 1ml per day, for 30 days
Cycle duration: 30 days
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