PRODUCT STRENGTH (CONCENTRATION)
WHAT ARE THE KEY BENEFITS?
- Food Approved
- Promotes leanness and hardness
- Clinical evidence of activity
- Long acting
SR900Prime is suitable for use by both males and females.
WHAT IS IT?
The Transient Receptor Potential cation Channel Member 8 (TRPM8) is an androgen receptor responsiblefor cell proliferation (reproduction), cell growth, and anabolic activity. It is also involved in the detection andmeasurement of cold temperatures.
Another function of TRPM8, is that it regulates energy metabolism, and controls the clock gene andclock-controlled genes in brown adipose (fat) tissue. This is achieved through upregulation of REV-ERBα/βgenes.
The ingredient N-Ethyl-p-menthane-3-carboxamide, found in SR900Prime, is a potent TRPM8 agonist (a substance which initiates aphysiological response when combined with a receptor).
The recently prohibited substances - SR9009 and SR9011, were observed to affect circadian expression of several core clock genes in thehypothalamus of mice. (suppression of cryptochrome 2; enhancement of period circadian clock 2; phase shift in BMAL1 and CLOCKexpression; and complete elimination of circadian expression of the neuronal PAS domain-containing protein2).
Dose-dependent suppression of the REV-ERB target plasminogen activator inhibitor 1 gene was observed in the liver in response to treatmentof mice with various doses over 6 days. Observations obtained when mice were kept under light:dark (12 h:12 h) conditions or completedarkness indicated that the effect of light on the circadian oscillator had a significant effect on the drug action. Moreover, circadian genesassociated with adipose tissue (fat) storage were found to be suppressed during treatment with the compounds.
SR900Prime is four times more potent than the ligand, menthol. Modulation of REV-ERB, CLOCK and CLOCK-like gene expression is furtherevidenced by menthol’s modulation of the sleep/wake cycles of various species with genes conserved in humans.It is reasonable to assume that the higher affinity for the TRPM8 and longer half-life in regard to metabolism, SR900Prime confers evengreater activity and comparable efficacy with SR9009.
ADMINISTRATION OF PRODUCT
Recommended dosage is 1ml (one full dropper) daily with food, administered in the morning, and mixed into 250ml juice, protein shake, orpre-workout.
- For weight loss: 1ml per day, for 30 days
- For leanness: 1ml per day, for 30 days
Cycle duration: 30 days
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